Article

Transcription-mediated organization of the replication initiation program across large genes sets up common fragile sites genome-wide

2019-07-25

Abstract excerpt

<h4>ABSTRACT</h4> Common Fragile Sites (CFSs) are chromosome regions prone to breakage under replication stress, known to drive chromosome rearrangements during oncogenesis. Most CFSs nest in large expressed genes, suggesting that transcription elicits their instability but the underlying mechanisms remained elusive. Analyses of genome-wide replication timing of human lymphoblasts here show that stress-induced de...

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Literature Corpus work: 8e9d0198-425e-56c4-9155-5ef613cd5752
DOI: 10.1101/714717

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