Article
Spatiotemporal regulation of DNA replication in the human genome and its association with genomic instability and disease.
Current medicinal chemistry - 1 Jan 2010
Watanabe Yoshihisa, Maekawa Masato
Abstract excerpt
The transmission of genetic information relies on a coordinated network of cell cycle controls. Abnormalities in this network can result in genomic instability and lead to the transformation of normal cells into cancer cells. Chromosomal DNA replication is not only central to cellular division but also plays a crucial role in the maintenance of genomic integrity. DNA replication errors increase genetic...
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