Article

High Resolution Repli-Seq defines the temporal choreography of initiation, elongation and termination of replication in mammalian cells

2019-09-05

Abstract excerpt

<h4>ABSTRACT</h4> DNA replication in mammalian cells occurs in a defined temporal order during S phase, known as the replication timing (RT) programme. RT is developmentally regulated and correlated with chromatin conformation and local transcriptional potential. Here we present RT profiles of unprecedented temporal resolution in two human embryonic stem cell lines, human colon carcinoma line HCT116 as well as F1...

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Literature Corpus work: 2df8df34-15ed-5e43-8491-5a81397f8ac5
DOI: 10.1101/755629

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