Article

Cohesin modulates DNA replication to preserve genome integrity

2021-12-07

Abstract excerpt

Cohesin participates in loop formation by extruding DNA fibers from its ring-shaped structure. Cohesin dysfunction eliminates chromatin loops but only causes modest transcription perturbation, which cannot fully explain the frequently observed mutations of cohesin in various cancers. Here, we found that DNA replication initiates at more than one thousand extra dormant origins after acute depletion of RAD21, a core...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 97b92756-30cc-5432-9601-d0be3837b937
DOI: 10.1101/2021.12.06.471507

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cohesin modulates DNA replication to preserve genome integrityDOI 10.1101/2021.12.06.471507Read

Cohesin-mediated loop anchors confine the location of human replication originsSemantic proximity Read

Replication stress underlies genomic instability at CTCF/cohesin-binding sites in cancerSemantic proximity Read

Multifaceted roles of cohesin in regulating transcriptional loopsSemantic proximity Read

Dormant replication origin firing links replication stress to whole chromosomal instability in human cancerSemantic proximity Read

Increased replication origin firing links replication stress to whole chromosomal instability in human cancerSemantic proximity Read

Cohesin association to replication sites depends on rad50 and promotes fork restart.Semantic proximity Read

Transcription and replication organize cohesin-dependent chromosome loopsSemantic proximity Read

Emerging themes in cohesin cancer biology.Semantic proximity Read

Cohesin loss eliminates all loop domains, leading to links among superenhancers and downregulation of nearby genesSemantic proximity Read

ATR and TopBP1 oppose to control dormant origin building, providing a first defence against replication stressSemantic proximity Read

Low replication stress leads to specific replication timing advances associated to chromatin remodelling in cancer cellsSemantic proximity Read

Pathways for maintenance of telomeres and common fragile sites during DNA replication stressSemantic proximity Read