Article

Error-corrected deep targeted sequencing of circulating cell-free DNA from colorectal cancer patients for sensitive detection of circulating tumor DNA

2023-12-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introduction</h4> Circulating tumor DNA (ctDNA) is a promising biomarker, reflecting the presence of tumor cells. Sequencing-based detection of ctDNA at low tumor fractions is challenging due to the crude error rate of sequencing. To mitigate this challenge, we developed UMIseq, a fixed-panel deep-targeted sequencing approach, which is universally applicable to all colorectal cancer (CRC) p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 50c378f6-0779-534f-a293-3a56c012cf2b
DOI: 10.1101/2023.12.22.573042

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Error-corrected deep targeted sequencing of circulating cell-free DNA from colorectal cancer patients for sensitive detection of circulating tumor DNADOI 10.1101/2023.12.22.573042Read

Error-Corrected Deep Targeted Sequencing of Circulating Cell-Free DNA from Colorectal Cancer Patients for Sensitive Detection of Circulating Tumor DNA.Semantic proximity Read

Combining mutation detection with fragmentomics features leads to improved tumor-informed ctDNA detectionSemantic proximity Read

Circulating Tumor DNA in Precision Oncology and Its Applications in Colorectal Cancer.Semantic proximity Read

Whole genome error-corrected sequencing for sensitive circulating tumor DNA cancer monitoringSemantic proximity Read

Error modelling of SNVs and indels in deep targeted cell-free DNA for sensitive detection of tumor burden in colorectal cancerSemantic proximity Read

Tumor-naïve ctDNA detection with deep learning-enhanced error suppression for sensitive mutation calling.Semantic proximity Read

Error-corrected flow-based sequencing at whole-genome scale and its application to circulating cell-free DNA profiling.Semantic proximity Read

Direct detection of early-stage cancers using circulating tumor DNA.Semantic proximity Read

Somatic copy number alteration and fragmentation analysis in circulating tumor DNA for cancer screening and treatment monitoring in colorectal cancer patients.Semantic proximity Read

Detection of circulating tumor DNA by tumor-informed whole-genome sequencing enables prediction of recurrence in stage III colorectal cancer patients.Semantic proximity Read

Machine learning enables detection of early-stage colorectal cancer by whole-genome sequencing of plasma cell-free DNASemantic proximity Read

Ultra-Sensitive Mutation Detection and Genome-Wide DNA Copy Number Reconstruction by Error-Corrected Circulating Tumor DNA Sequencing.Semantic proximity Read