Article

Combining mutation detection with fragmentomics features leads to improved tumor-informed ctDNA detection

2026-04-01

Abstract excerpt

Liquid biopsy through circulating tumor DNA (ctDNA) analysis enables non-invasive detection of minimal residual disease (MRD) and early identification of cancer relapse, facilitating timely clinical intervention. However, detecting ctDNA in plasma samples with low tumor burden remains challenging due to the scarcity of mutant molecules, the background noise of sequencing errors and somatic mutations in normal cell...

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Literature Corpus work: 14cd487f-80ce-5f83-ab5c-45d37ce205ef
DOI: 10.64898/2026.03.30.714025

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