Detection of circulating tumor DNA by tumor-informed whole-genome sequencing enables prediction of recurrence in stage III colorectal cancer patients.

doi:10.1016/j.ejca.2024.114314

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Article

Detection of circulating tumor DNA by tumor-informed whole-genome sequencing enables prediction of recurrence in stage III colorectal cancer patients.

European journal of cancer (Oxford, England : 1990) - 1 Nov 2024

Frydendahl Amanda, Nors Jesper, Rasmussen Mads H, Henriksen Tenna V, Nesic Marijana, Reinert Thomas, Afterman Danielle, Lauterman Tomer, Kuzman Maja, Gonzalez Santiago, Glavas Dunja, Smadback James, Maloney Dillon, Levativ Jurica, Yahalom Michael, Ptashkin Ryan, Tavassoly Iman, Donenhirsh Zohar, White Eric, Kandasamy Ravi, Alon Ury, Nordentoft Iver, Lindskrog Sia V, Dyrskjøt Lars, Jaensch Claudia, Løve Uffe S, Andersen Per V, Thorlacius-Ussing Ole, Iversen Lene H, Gotschalck Kåre A, Zviran Asaf, Oklander Boris, Andersen Claus L

Abstract excerpt

INTRODUCTION: Circulating tumor (ctDNA) can be used to detect residual disease after cancer treatment. Detecting low-level ctDNA is challenging, due to the limited number of recoverable ctDNA fragments at any target loci. In response, we applied tumor-informed whole-genome sequencing (WGS), leveraging thousands of mutations for ctDNA detection. METHODS: Performance was evaluated in serial plasma samples...

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PMID: 39316995
DOI: 10.1016/j.ejca.2024.114314

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