Article

Error modelling of SNVs and indels in deep targeted cell-free DNA for sensitive detection of tumor burden in colorectal cancer

2026-06-02

Abstract excerpt

Circulating tumor DNA (ctDNA) is a promising biomarker for cancer detection, but low tumor burden makes it difficult to distinguish true signal from background noise. To aggregate and better evaluate weak mutational signals, we propose PyDREAMS, which incorporates both single-nucleotide variants (SNVs) and insertion and deletions (indels) for ctDNA detection and quantification. To distinguish signal from noise, a...

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Literature Corpus work: 8d0f9084-f9dc-582f-ac7a-3c13084a1848
DOI: 10.64898/2026.05.29.728727

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