Article

Whole genome error-corrected sequencing for sensitive circulating tumor DNA cancer monitoring

2022-11-17

Abstract excerpt

<h4>ABSTRACT</h4> Circulating cell-free DNA (ccfDNA) sequencing for low-burden cancer monitoring is limited by sparsity of circulating tumor DNA (ctDNA), the abundance of genomic material within a plasma sample, and pre-analytical error rates due to library preparation, and sequencing errors. Sequencing costs have historically favored the development of deep targeted sequencing approaches for overcoming sparsity...

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Literature Corpus work: 96331aa9-afa8-5334-8484-399880f5de8c
DOI: 10.1101/2022.11.17.516904

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