Article
Direct detection of early-stage cancers using circulating tumor DNA.
Science translational medicine - 16 Aug 2017
Phallen Jillian, Sausen Mark, Adleff Vilmos, Leal Alessandro, Hruban Carolyn, White James, Anagnostou Valsamo, Fiksel Jacob, Cristiano Stephen, Papp Eniko, Speir Savannah, Reinert Thomas, Orntoft Mai-Britt Worm, Woodward Brian D, Murphy Derek, Parpart-Li Sonya, Riley David, Nesselbush Monica, Sengamalay Naomi, Georgiadis Andrew, Li Qing Kay, Madsen Mogens Rørbæk, Mortensen Frank Viborg, Huiskens Joost, Punt Cornelis, van Grieken Nicole, Fijneman Remond, Meijer Gerrit, Husain Hatim, Scharpf Robert B, Diaz Luis A, Jones Siân, Angiuoli Sam, Ørntoft Torben, Nielsen Hans Jørgen, Andersen Claus Lindbjerg, Velculescu Victor E
Abstract excerpt
Early detection and intervention are likely to be the most effective means for reducing morbidity and mortality of human cancer. However, development of methods for noninvasive detection of early-stage tumors has remained a challenge. We have developed an approach called targeted error correction sequencing (TEC-Seq) that allows ultrasensitive direct evaluation of sequence changes in circulating cell-free DNA...
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