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Article

Error-Corrected Deep Targeted Sequencing of Circulating Cell-Free DNA from Colorectal Cancer Patients for Sensitive Detection of Circulating Tumor DNA.

International journal of molecular sciences - 11 Apr 2024

Frydendahl Amanda, Rasmussen Mads Heilskov, Jensen Sarah Østrup, Henriksen Tenna Vesterman, Demuth Christina, Diekema Mathilde, Ditzel Henrik Jørn, Wen Sara Witting Christensen, Pedersen Jakob Skou, Dyrskjøt Lars, Andersen Claus Lindbjerg

Abstract excerpt

Circulating tumor DNA (ctDNA) is a promising biomarker, reflecting the presence of tumor cells. Sequencing-based detection of ctDNA at low tumor fractions is challenging due to the crude error rate of sequencing. To mitigate this challenge, we developed ultra-deep mutation-integrated sequencing (UMIseq), a fixed-panel deep targeted sequencing approach, which is universally applicable to all colorectal cancer...

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Source

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Identifiers

PMID: 38673836
DOI: 10.3390/ijms25084252
PMCID: PMC11049993

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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