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Article

Tumor-naïve ctDNA detection with deep learning-enhanced error suppression for sensitive mutation calling.

Genome medicine - 23 Jun 2026

Akbarinejad Shaya, Doppler Sarah, Graaf Jos de, Pistolic-Kraft Jelena, Bukur Valesca, Albrecht Christian, Buchholz Nathalie, Özenoglu Simge, Sahin Ugur, Ibn-Salem Jonas, Weber David

Abstract excerpt

BACKGROUND: Circulating tumor DNA (ctDNA) detection offers minimally invasive monitoring of cancer from blood samples. While tumor-informed approaches are sensitive, their clinical application is limited by cost, tissue availability, and turnaround time. In contrast, tumor-naïve assays offer faster turnaround times and broader applicability, but often sacrifice sensitivity. METHODS: Here, we developed DEEPctMUT,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42332784
DOI: 10.1186/s13073-026-01694-y
PMCID: PMC13289477

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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