Article
Somatic copy number alteration and fragmentation analysis in circulating tumor DNA for cancer screening and treatment monitoring in colorectal cancer patients.
Journal of hematology & oncology - 2 Sept 2022
Hallermayr Ariane, Wohlfrom Tobias, Steinke-Lange Verena, Benet-Pagès Anna, Scharf Florentine, Heitzer Ellen, Mansmann Ulrich, Haberl Christopher, de Wit Maike, Vogelsang Holger, Rentsch Markus, Holinski-Feder Elke, Pickl Julia M A
Abstract excerpt
BACKGROUND: Analysis of circulating free DNA (cfDNA) is a promising tool for personalized management of colorectal cancer (CRC) patients. Untargeted cfDNA analysis using whole-genome sequencing (WGS) does not need a priori knowledge of the patient´s mutation profile. METHODS: Here we established LIquid biopsy Fragmentation, Epigenetic signature and Copy Number Alteration analysis (LIFE-CNA) using WGS...
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