Article

Machine learning enables detection of early-stage colorectal cancer by whole-genome sequencing of plasma cell-free DNA

2018-11-24

Abstract excerpt

<h4>Background</h4> Blood-based methods using cell-free DNA (cfDNA) are under development as an alternative to existing screening tests. However, early-stage detection of cancer using tumor-derived cfDNA has proven challenging because of the small proportion of cfDNA derived from tumor tissue in early-stage disease. A machine learning approach to discover signatures in cfDNA, potentially reflective of both tumor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3dfc567a-3036-5809-8afd-685087fd3eed
DOI: 10.1101/478065

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Machine learning enables detection of early-stage colorectal cancer by whole-genome sequencing of plasma cell-free DNADOI 10.1101/478065Read

Machine learning enables detection of early-stage colorectal cancer by whole-genome sequencing of plasma cell-free DNASemantic proximity Read

Early detection and stratification of colorectal cancer using plasma cell-free DNA fragmentomic profilingSemantic proximity Read

Somatic copy number alteration and fragmentation analysis in circulating tumor DNA for cancer screening and treatment monitoring in colorectal cancer patients.Semantic proximity Read

Plasma cell-free DNA as a sensitive biomarker for multi-cancer detection and immunotherapy outcomes predictionSemantic proximity Read

Pan-cancer detection and typing by mining patterns in large genome-wide cell-free DNA sequencing datasetsSemantic proximity Read

Ultra-low coverage fragmentomic model of cell-free DNA for cancer detection based on whole-exome regionsSemantic proximity Read

Use of Circulating Cell-Free DNA to Guide Precision Medicine in Patients with Colorectal Cancer.Semantic proximity Read

Machine learning identifies cell-free DNA 5-hydroxymethylation biomarkers that detect occult colorectal cancer in PLCO Screening Trial subjectsSemantic proximity Read

Machine Learning‐Assisted Evaluation of Circulating DNA Quantitative Analysis for Cancer ScreeningSemantic proximity Read

Assay Validation of Cell-Free DNA Shallow Whole-Genome Sequencing to Determine Tumor Fraction in Advanced CancersSemantic proximity Read

Plasma cell-free DNA (cfDNA) assays for early multi-cancer detection: The circulating cell-free genome atlas (CCGA) studySemantic proximity Read

Error-corrected deep targeted sequencing of circulating cell-free DNA from colorectal cancer patients for sensitive detection of circulating tumor DNASemantic proximity Read