Article

Deletion of a Distal IRF4 Element Prevents Inflammation-induced Reprogramming of Human Regulatory T-cell Fate

2024-11-07

Abstract excerpt

<title>Abstract</title> <p>Adoptive regulatory T cell (Treg) therapy is an emergent treatment paradigm for restoring immune tolerance in patients with autoimmune and inflammatory diseases. While preclinical models have demonstrated the remarkable efficacy of Treg cell therapy, lineage-tracing studies have also revealed that murine Tregs can lose lineage identity and adopt a proinflammatory state. Whether human Tr...

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Literature Corpus work: 4fa2796a-50e8-5b40-bd3f-7387d6f8cf66
DOI: 10.21203/rs.3.rs-5356932/v1

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