Article
Histone methylation mediates plasticity of human FOXP3(+) regulatory T cells by modulating signature gene expressions.
Immunology - 1 Mar 2014
He Haiqi, Ni Bing, Tian Yi, Tian Zhiqiang, Chen Yanke, Liu Zhengwen, Yang Xiaomei, Lv Yi, Zhang Yong
Abstract excerpt
CD4(+) FOXP3(+) regulatory T (Treg) cells constitute a heterogeneous and plastic T-cell lineage that plays a pivotal role in maintaining immune homeostasis and immune tolerance. However, the fate of human Treg cells after loss of FOXP3 expression and the epigenetic mechanisms contributing to such a phenotype switch remain to be fully elucidated. In the current study, we demonstrate that human CD4(+) CD25(high)...
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