Article

Human regulatory T-cells locally differentiate and are functionally heterogeneous within the inflamed arthritic joint

2022-02-20

Abstract excerpt

<h4>Objective</h4> Tregs are crucial for immune regulation, and environment-driven adaptation of effector (e)Tregs is essential for local functioning. However, the extent of human Treg heterogeneity in inflammatory settings is unclear. <h4>Methods</h4> We combined single-cell RNA- and TCR-sequencing on Tregs derived from 4-6 patients with juvenile idiopathic arthritis (JIA) to investigate the functional heteroge...

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Literature Corpus work: d6b01520-e24c-5e9e-915d-64434062974f
DOI: 10.1101/2022.02.18.480998

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