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Article

Increased phenotypic and functional stability of human allospecific induced Tregs is associated with Vitamin C-mediated FOXP3 TSDR demethylation.

Frontiers in immunology - 1 Jan 2026

Alvarez-Salazar Evelyn K, Reyes-Barrientos Judith E, Cortés-Hernández Arimelek, Saint-Martin Castellanos Abril, Arteaga-Cruz Saúl, Cervera Alejandra, Martínez-Iturbe Iyari, Sánchez-Hernández Beatriz E, Gamboa-Domínguez Armando, Soldevila Gloria

Abstract excerpt

Introduction: While numerous preclinical models emphasize the therapeutic promise of in vitro-induced Tregs (iTregs) for managing inflammatory diseases and promoting tolerance, their translation to clinical use is limited by concerns over phenotypic and functional instability, largely due to an epigenetic profile distinct from thymic Tregs. Methods: To address this, we generated and expanded iTregs in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42488647
DOI: 10.3389/fimmu.2026.1827886
PMCID: PMC13388274

Genes

FOXP3
CCR4
CCR5
CD4
CXCR3
TIGIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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