Article
Beyond FOXP3: a 20-year journey unravelling human regulatory T-cell heterogeneity.
Frontiers in immunology - 1 Jan 2023
Santosh Nirmala Samikshya, Kayani Kayani, Gliwiński Mateusz, Hu Yueyuan, Iwaszkiewicz-Grześ Dorota, Piotrowska-Mieczkowska Magdalena, Sakowska Justyna, Tomaszewicz Martyna, Marín Morales José Manuel, Lakshmi Kavitha, Marek-Trzonkowska Natalia Maria, Trzonkowski Piotr, Oo Ye Htun, Fuchs Anke
Abstract excerpt
The initial idea of a distinct group of T-cells responsible for suppressing immune responses was first postulated half a century ago. However, it is only in the last three decades that we have identified what we now term regulatory T-cells (Tregs), and subsequently elucidated and crystallized our understanding of them. Human Tregs have emerged as essential to immune tolerance and the prevention of autoimmune...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.