Article

Loss of TET function in T regulatory cells yields ex-Treg cells biased toward T follicular helper cells, causing autoimmune diseases through autoantibody production

2025-09-03

Abstract excerpt

<h4>ABSTRACT</h4> T regulatory cells (Treg cells) express the transcription factor FOXP3 and maintain immune homeostasis by attenuating effector responses. Treg cells are prone to lose FOXP3 and convert to pathological ‘ex-Treg’ cells under conditions of strong or chronic inflammation. One mechanism for loss of FOXP3 expression involves increased DNA methylation of intronic enhancers CNS1 and CNS2 in the Foxp3...

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Literature Corpus work: d3410f05-db4c-50a7-8241-3c5c866087c8
DOI: 10.1101/2025.08.29.673187

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