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Article

Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases.

Cell research - 1 Jun 2020

Ohkura Naganari, Sakaguchi Shimon

Abstract excerpt

Naturally arising regulatory CD4+ T (Treg) cells, which specifically express the transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a T-cell subpopulation specialized for immune suppression, playing a key role in maintaining immunological self-tolerance and homeostasis. FoxP3 is required for Treg function, especially for its suppressive activity. However, FoxP3 expression per...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Forkhead Transcription Factors

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Identifiers

PMID: 32367041
DOI: 10.1038/s41422-020-0324-7
PMCID: PMC7264322

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