Article

Profound Treg perturbations correlate with COVID-19 severity

2020-12-11

Abstract excerpt

<h4>Summary</h4> The hallmark of severe COVID-19 disease has been an uncontrolled inflammatory response, resulting from poorly understood immunological dysfunction. We explored the hypothesis that perturbations in FoxP3+ T regulatory cells (Treg), key enforcers of immune homeostasis, contribute to COVID-19 pathology. Cytometric and transcriptomic profiling revealed a distinct Treg phenotype in severe COVID-19 pat...

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Literature Corpus work: 27064152-cd75-57c3-97d5-29133bd83282
DOI: 10.1101/2020.12.11.416180

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