Article

Ikzf1 association with Foxp3 for Foxp3-dependent gene repression in Treg cells: induction of autoimmunity and tumor immunity by disrupting the association

2023-08-14

Abstract excerpt

<h4>SUMMARY</h4> The transcription factor Foxp3 specifically expressed in regulatory T (Treg) cells controls Treg function by repressing some genes and activating others. We have shown here that the transcription factor Ikzf1 associates with Foxp3 via its exon 5 (called IkE5) and that conditional deletion of IkE5 up-regulated the genes, including Ifng , normally repressed by Foxp3 upon TCR stimulation. IkE5 -d...

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Literature Corpus work: 6d46d779-9c76-5ee6-894f-00a2a88bc761
DOI: 10.1101/2023.08.12.553084

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