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Article

Diffusion MRI in 2-Month-Old Mouse Brain Predicts Alzheimer's Pathology Genotype.

NMR in biomedicine - 1 Apr 2025

Falangola Maria Fatima, Granger Bryan, Voltin Joshua, Nietert Paul J, Berto Stefano, Jensen Jens H

Abstract excerpt

Diffusion MRI (dMRI) is widely used as a non-invasive means of detecting changes in brain tissue microstructure. In our previous studies, we demonstrated the sensitivity of dMRI to capture brain microstructural alterations in the triple transgenic (3xTg-AD) mice, particularly brain morphological abnormalities in 2-month-old mice, where dMRI was sensitive to myelin abnormalities, to microglia...

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PMID: 40037790
DOI: 10.1002/nbm.70018
PMCID: PMC12764334

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