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Article

Systems modeling of white matter microstructural abnormalities in Alzheimer's disease.

NeuroImage. Clinical - 1 Jan 2020

Horgusluoglu-Moloch Emrin, Xiao Gaoyu, Wang Minghui, Wang Qian, Zhou Xianxiao, Nho Kwangsik, Saykin Andrew J, Schadt Eric, Zhang Bin

Abstract excerpt

INTRODUCTION: Microstructural abnormalities in white matter (WM) are often reported in Alzheimer's disease (AD). However, it is unclear which brain regions have the strongest WM changes in presymptomatic AD and what biological processes underlie WM abnormality during disease progression. METHODS: We developed a systems biology framework to integrate matched diffusion tensor imaging (DTI), genetic and...

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Identifiers

PMID: 32062565
DOI: 10.1016/j.nicl.2020.102203
PMCID: PMC7025138

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