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Article

The interaction effects of age, APOE and common environmental risk factors on human brain structure.

Cerebral cortex (New York, N.Y. : 1991) - 14 Jan 2024

Chen Jie, Li Tengfei, Zhao Bingxin, Chen Hui, Yuan Changzheng, Garden Gwenn A, Wu Guorong, Zhu Hongtu

Abstract excerpt

Mounting evidence suggests considerable diversity in brain aging trajectories, primarily arising from the complex interplay between age, genetic, and environmental risk factors, leading to distinct patterns of micro- and macro-cerebral aging. The underlying mechanisms of such effects still remain unclear. We conducted a comprehensive association analysis between cerebral structural measures and prevalent risk...

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Identifiers

PMID: 38112569
DOI: 10.1093/cercor/bhad472
PMCID: PMC10793588

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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