Article

The Interaction Effects of Age, APOE and Common Environmental Risk Factors on Human brain Structure

2022-11-01

Abstract excerpt

Mounting evidence suggests considerable diversity in brain aging trajectories, primarily arising from the complex interplay between age, genetic and environmental risk factors, leading to distinct patterns of micro- and macro-cerebral aging. The underlying mechanisms of such effects still remain unclear. We conducted a comprehensive association analysis between cerebral structural measures and prevalent risk facto...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9d5a97fc-0544-559d-95c6-d4dfa246ee14
DOI: 10.1101/2022.10.30.22281690

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Interaction Effects of Age, APOE and Common Environmental Risk Factors on Human brain StructureDOI 10.1101/2022.10.30.22281690Read

The interaction effects of age, APOE and common environmental risk factors on human brain structure.Semantic proximity Read

The Interaction Effects of Sex, Age, APOE and Common Health Risk Factors on Human Brain FunctionsSemantic proximity Read

Brain aging comprises many modes of structural and functional change with distinct genetic and biophysical associationsSemantic proximity Read

Nongenetic and Genetic Factors Associated with White Matter Brain Aging: Exposome-Wide and Genome-Wide Association Study.Semantic proximity Read

APOE, Immune Factors, Sex, and Diet Interact to Shape Brain Networks in Mouse Models of AgingSemantic proximity Read

Neurostructural and cognitive signatures of novel polygenic risk scores for molecular brain agingSemantic proximity Read

Neurostructural and cognitive signatures of novel polygenic risk scores for molecular brain agingSemantic proximity Read

Is there association between <i>APOE</i> e4 genotype and structural brain ageing phenotypes, and does that association increase in older age in UK Biobank? (N = 8,395)Semantic proximity Read

Associations of<i>APOE</i>e2/e4 dosage and lifestyle on neuroimaging markers in the UK BiobankSemantic proximity Read

The Genetic Architecture of Multimodal Human Brain AgeSemantic proximity Read

A comprehensive analysis of <i>APOE</i> genotype effects on human brain structure in the UK BiobankSemantic proximity Read

Polygenic risk for Alzheimer's disease in healthy aging: age-related and APOE-driven effects on brain structures and cognition.Semantic proximity Read