Article
Cell type-specific epigenetic regulatory circuitry of coronary artery disease loci.
Nature communications - 10 Mar 2026
Hecker Dennis, Song Xiaoning, Baumgarten Nina, Diagel Anastasiia, Katsaouni Nikoletta, Li Ling, Li Shuangyue, Kumar Maji Ranjan, Behjati Ardakani Fatemeh, Ma Lijiang, Li Zhaolong, Moggio Aldo, Tews Daniel, Sager Hendrik, Maegdefessel Lars, Wabitsch Martin, Björkegren Johan L M, Schunkert Heribert, Chen Zhifen, Schulz Marcel H
Abstract excerpt
Coronary artery disease is the leading cause of death worldwide. Recently, hundreds of genomic loci have been shown to increase risk for the disease, however, the molecular mechanisms underlying signals from risk loci remain largely unclear. Here, we integrate the latest statistics of coronary artery disease genetics from over one million individuals with epigenetic data from 45 cell types to identify genes and...
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