Article

Coronary Artery Disease Risk Gene <i>PRDM16</i> is Preferentially Expressed in Vascular Smooth Muscle Cells and a Potential Novel Regulator of Smooth Muscle Homeostasis

2023-04-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Vascular smooth muscle cells (VSMCs) are the primary contractile component of blood vessels and can undergo phenotypic switching from a contractile to a synthetic phenotype in vascular diseases such as coronary artery disease (CAD). This process leads to decreased expression of SMC lineage genes and increased proliferative, migratory and secretory abilities that drive disease...

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Literature Corpus work: dc4c4ab5-abdb-5268-bbe9-4c66f3cca650
DOI: 10.1101/2023.04.03.535461

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