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Article

Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci.

Nature communications - 8 Jul 2016

Miller Clint L, Pjanic Milos, Wang Ting, Nguyen Trieu, Cohain Ariella, Lee Jonathan D, Perisic Ljubica, Hedin Ulf, Kundu Ramendra K, Majmudar Deshna, Kim Juyong B, Wang Oliver, Betsholtz Christer, Ruusalepp Arno, Franzén Oscar, Assimes Themistocles L, Montgomery Stephen B, Schadt Eric E, Björkegren Johan L M, Quertermous Thomas

Abstract excerpt

Coronary artery disease (CAD) is the leading cause of mortality and morbidity, driven by both genetic and environmental risk factors. Meta-analyses of genome-wide association studies have identified >150 loci associated with CAD and myocardial infarction susceptibility in humans. A majority of these variants reside in non-coding regions and are co-inherited with hundreds of candidate regulatory variants,...

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Source

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Identifiers

PMID: 27386823
DOI: 10.1038/ncomms12092
PMCID: PMC4941121

Genes

CAD
BMP1
CCDC97
LMOD1
PDGFD
SMAD3
TGFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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