Article

Quantification of the escape from X chromosome inactivation with the million cell-scale human single-cell omics datasets reveals heterogeneity of escape across cell types and tissues

2023-10-18

Abstract excerpt

One of the two X chromosomes of females is silenced through X chromosome inactivation (XCI) to compensate for the difference in the dosage between sexes. Among the X-linked genes, several genes escape from XCI, which could contribute to the differential gene expression between the sexes. However, the differences in the escape across cell types and tissues are still poorly characterized because no methods could dir...

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Literature Corpus work: 8a051583-40f1-53e2-bfc7-5cacbf43e952
DOI: 10.1101/2023.10.14.561800

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