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Article

Inferring genes that escape X-Chromosome inactivation reveals important contribution of variable escape genes to sex-biased diseases.

Genome research - 1 Sept 2021

Sauteraud Renan, Stahl Jill M, James Jesica, Englebright Marisa, Chen Fang, Zhan Xiaowei, Carrel Laura, Liu Dajiang J

Abstract excerpt

The X Chromosome plays an important role in human development and disease. However, functional genomic and disease association studies of X genes greatly lag behind autosomal gene studies, in part owing to the unique biology of X-Chromosome inactivation (XCI). Because of XCI, most genes are only expressed from one allele. Yet, ∼30% of X genes "escape" XCI and are transcribed from both alleles, many only in a...

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Identifiers

PMID: 34426515
DOI: 10.1101/gr.275677.121
PMCID: PMC8415373

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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