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Article

Escape from X-inactivation in twins exhibits intra- and inter-individual variability across tissues and is heritable.

PLoS genetics - 1 Feb 2023

Zito Antonino, Roberts Amy L, Visconti Alessia, Rossi Niccolo', Andres-Ejarque Rosa, Nardone Stefano, El-Sayed Moustafa Julia S, Falchi Mario, Small Kerrin S

Abstract excerpt

X-chromosome inactivation (XCI) silences one X in female cells to balance sex-differences in X-dosage. A subset of X-linked genes escape XCI, but the extent to which this phenomenon occurs and how it varies across tissues and in a population is as yet unclear. To characterize incidence and variability of escape across individuals and tissues, we conducted a transcriptomic study of escape in adipose, skin,...

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Share to Chromosomes, Human, X
Share to Genes, X-Linked

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Twins, Monozygotic

Share to X Chromosome Inactivation

Source

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Identifiers

PMID: 36802379
DOI: 10.1371/journal.pgen.1010556
PMCID: PMC9942974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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