Article

Extensive cellular heterogeneity of X inactivation revealed by single-cell allele-specific expression in human fibroblasts

2018-04-10

Abstract excerpt

<h4>ABSTRACT</h4> In eutherian mammals, X chromosome inactivation (XCI) provides a dosage compensation mechanism where in each female cell one of the two X chromosomes is randomly silenced. However, some genes on the inactive X chromosome and outside the pseudoautosomal regions escape from XCI and are expressed from both alleles (escapees). Given the relevance of the escapees in biology and medicine, we investiga...

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Literature Corpus work: 8a372483-0af1-5a14-b2e9-618cfbd0c4b4
DOI: 10.1101/298984

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