Article

Cohesin loading at regulatory elements shapes 3D genome folding during erythropoiesis

2026-08-06

Abstract excerpt

During erythropoiesis, differentiating cells silence much of the genome while maintaining high expression of select genes. It remains unclear whether this transcriptional specialization is linked to specific changes in 3D genome organization. We generated deep Micro-C maps across human erythropoiesis and identified erythroid cis -regulatory elements (CREs) that function as “matchmakers” by strengthening loops bet...

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Literature Corpus work: 4af63e18-ca95-5796-8386-5a6dda84e01f
DOI: 10.64898/2026.08.02.741886

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