Article

Trimodal Single-Cell Gene Regulatory Networks Reveal Principles of Stemness Loss and Cell Fate Acquisition in Human Hematopoiesis

2025-09-16

Abstract excerpt

<h4>Summary</h4> Hematopoiesis requires the coordinated loss of stemness and acquisition of lineage identity, yet the regulatory logic and principles underlying these transitions has remained elusive. Single-cell studies suggest that hematopoietic stem and progenitor cells progress along continuous trajectories, but this view conflicts with the existence of discrete, functionally validated populations. Here, we e...

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Literature Corpus work: f940ed7c-ffae-5e19-a60c-c544f48e36d3
DOI: 10.1101/2025.09.11.675740

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