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Article

Comprehensive 3D epigenomic maps define limbal stem/progenitor cell function and identity

11 Mar 2022

Abstract excerpt

The insights into how genome topology couples with epigenetic states to govern the function and identity of the corneal epithelium are poorly understood. Here, we generate a high-resolution Hi-C interaction map of human limbal stem/progenitor cells (LSCs) and show that chromatin multi-hierarchical organisation is coupled to gene expression. By integrating Hi-C, epigenome and transcriptome data, we characterize...

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PMID: 35277509
DOI: 10.1038/s41467-022-28966-6

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