Article

A Cell type-specific Class of Chromatin Loops Anchored at Large DNA Methylation Nadirs

2017-11-09

Abstract excerpt

Higher order chromatin structure and DNA methylation are implicated in multiple developmental processes, but their relationship to cell state is unknown. Here, we found that large (~10kb) DNA methylation nadirs can form long loops connecting anchor loci that may be dozens of megabases apart, as well as interchromosomal links. The interacting loci comprise ~3.5Mb of the human genome. The data are more consistent wi...

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Literature Corpus work: d8ac6b15-5452-531b-adb2-89095560fe2d
DOI: 10.1101/212928

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