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Article

Static and Dynamic DNA Loops form AP-1-Bound Activation Hubs during Macrophage Development.

Molecular cell - 21 Sept 2017

Phanstiel Douglas H, Van Bortle Kevin, Spacek Damek, Hess Gaelen T, Shamim Muhammad Saad, Machol Ido, Love Michael I, Aiden Erez Lieberman, Bassik Michael C, Snyder Michael P

Abstract excerpt

The three-dimensional arrangement of the human genome comprises a complex network of structural and regulatory chromatin loops important for coordinating changes in transcription during human development. To better understand the mechanisms underlying context-specific 3D chromatin structure and transcription during cellular differentiation, we generated comprehensive in situ Hi-C maps of DNA loops in human...

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Share to Cell Differentiation
Share to Chromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin Assembly and Disassembly

Share to Enhancer Elements, Genetic

Share to High-Throughput Nucleotide Sequencing

Share to Macrophages

Share to Nucleic Acid Conformation

Share to Transcription Factor AP-1

Source

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Identifiers

PMID: 28890333
DOI: 10.1016/j.molcel.2017.08.006
PMCID: PMC5610110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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