Article

H3K27M-driven hypertranscription leads to a new targetable dependency in diffuse midline gliomas

2026-05-15

Abstract excerpt

Diffuse midline gliomas (DMGs) are driven by the H3K27M oncohistone—a challenging therapeutic target. However, conventional therapeutic modalities are never curative. Against this backdrop, we address an important unresolved question--are there H3K27M-induced oncogenic vulnerabilities that can be exploited for therapeutic benefit. We show that H3K27M induces hypertranscription, thus identifying hypertranscription...

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Literature Corpus work: 2d4b3b80-43a5-5821-9d9c-2fa938fd2e05
DOI: 10.64898/2026.05.12.724628

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