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Article

H3F3A K27M mutations drive a repressive transcriptome by modulating chromatin accessibility independent of H3K27me3 in Diffuse Midline Glioma.

Epigenetics & chromatin - 26 Apr 2025

Bhattarai Suraj, Hakkim Faruck L, Day Charles A, Grigore Florina, Langfald Alyssa, Entin Igor, Hinchcliffe Edward H, Robinson James P

Abstract excerpt

BACKGROUND: Heterozygous histone H3.3K27M mutation is a primary oncogenic driver of Diffuse Midline Glioma (DMG). H3.3K27M inhibits the Polycomb Repressive Complex 2 (PRC2) methyltransferase activity, leading to global reduction and redistribution of the repressive H3 lysine 27 tri-methylation (H3K27me3). This epigenomic rewiring is thought to promote gliomagenesis, but the precise role of K27M in gene regulation...

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PMID: 40287708
DOI: 10.1186/s13072-025-00585-7
PMCID: PMC12032731

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