Article
Cell autonomous regional differences in oligodendrocyte lineage development and responses to oncohistone H3.3 K27M.
Nature communications - 26 Aug 2026
Andrews Jared M, Budd Kaitlin M, Kwon Chang-Hyuk, Larson Jon D, Shirinifard Abbas, Kasper Lawryn H, Williams Chanrika C, Lavado Alfonso, King Sharon, Gutierrez Jorge, Stabley Daniel, Lin Tong, Lewis Sara A, Northcott Paul A, Onar-Thomas Arzu, Baker Suzanne J
Abstract excerpt
Diffuse midline glioma, H3K27-altered (DMG), is a lethal midline brain tumor. Most DMG, unlike glioma arising in other regions, harbor histone H3.3 K27M (K27M) mutations. The basis for this anatomical selectivity remains unclear. Stem-like DMG cell transcriptomes most resemble oligodendrocyte precursor cells (OPCs). Using conditional K27M knock-in mice, we show that K27M reduces oligodendrocyte differentiation,...
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