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Article

Evidence for coordinate CTCF and histone H3.3 activities in K27M diffuse midline gliomas.

Acta neuropathologica communications - 2 May 2026

Klein Rachel H, Yee Jennifer Q, Knoepfler Paul S

Abstract excerpt

Up to 80% of diffuse midline gliomas (DMGs) are characterized by a lysine to methionine driver mutation (K27M) in the tail of histone variant H3.3, pointing to likely roles for epigenetic mechanisms in K27M-driven tumorigenesis. Understanding the effects of mutant histone H3.3 on the complex patterns of histone modifications and interactions with chromatin structure and modifying enzymes is essential to...

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Share to Brain Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Source

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Identifiers

PMID: 42070015
DOI: 10.1186/s40478-026-02290-2
PMCID: PMC13288838

Genes

CTCF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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