Article

H3F3A K27M Mutations Drives a Repressive Transcriptome by Modulating Chromatin Accessibility, Independent of H3K27me3 in Diffuse Midline Glioma

2024-05-18

Abstract excerpt

<h4>Background</h4> Heterozygous histone H3.3K27M mutation is a primary oncogenic driver of Diffuse Midline Glioma (DMG). H3.3K27M inhibits the Polycomb Repressive Complex 2 (PRC2) methyltransferase complex, leading to a global reduction and redistributing of the repressive H3 lysine 27 tri-methylation. This rewiring of the epigenome is thought to promote gliomagenesis. <h4>Methods</h4> We established novel, iso...

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Literature Corpus work: 87ba7ff4-2836-55b8-8514-7ac21475d704
DOI: 10.1101/2024.05.16.594522

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