Article

H3.1K27M-induced misregulation of the TSK/TONSL-H3.1 pathway causes genomic instability

2024-12-11

Abstract excerpt

The oncomutation lysine 27-to-methionine in histone H3 (H3K27M) is frequently identified in tumors of patients with diffuse midline glioma-H3K27 altered (DMG-H3K27a). H3K27M inhibits the deposition of the histone mark H3K27me3, which affects the maintenance of transcriptional programs and cell identity. Cells expressing H3K27M are also characterized by defects in genome integrity, but the mechanisms linking expres...

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Literature Corpus work: 1d18e0a8-f166-545b-8a7b-150ad34caf0f
DOI: 10.1101/2024.12.09.627617

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