Article

<i>regionalpcs</i> : improved discovery of DNA methylation associations with complex traits

2024-05-01

Abstract excerpt

We have developed the regional principal components (rPCs) method, a novel approach for summarizing gene-level methylation. rPCs address the challenge of deciphering complex epigenetic mechanisms in diseases like Alzheimer’s disease (AD). In contrast to traditional averaging, rPCs leverage principal components analysis to capture complex methylation patterns across gene regions. Our method demonstrated a 54% impro...

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Literature Corpus work: 491664ec-2d7b-5886-92da-2af8df989c5b
DOI: 10.1101/2024.05.01.590171

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