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Article

regionalpcs improve discovery of DNA methylation associations with complex traits.

Nature communications - 3 Jan 2025

Eulalio Tiffany, Sun Min Woo, Gevaert Olivier, Greicius Michael D, Montine Thomas J, Nachun Daniel, Montgomery Stephen B

Abstract excerpt

We have developed the regionalpcs method, an approach for summarizing gene-level methylation. regionalpcs addresses the challenge of deciphering complex epigenetic mechanisms in diseases like Alzheimer's disease. In contrast to averaging, regionalpcs uses principal components analysis to capture complex methylation patterns across gene regions. Our method demonstrates a 54% improvement in sensitivity over...

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Identifiers

PMID: 39753567
DOI: 10.1038/s41467-024-55698-6
PMCID: PMC11698866

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