Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mendelian randomization integrating GWAS and mQTL data identified novel pleiotropic DNA methylation loci for neuropathology of Alzheimer's disease.

Neurobiology of aging - 1 Jan 2021

Liu Di, Wang Youxin, Jing Huiquan, Meng Qun, Yang Jingyun

Abstract excerpt

The pathogenesis of Alzheimer's disease (AD) remains largely unclear. Exploring the genetic/epigenetic loci showing pleiotropic association with the neuropathologies of AD may greatly enhance understanding of the mechanisms underlying the development of AD. In this study, using data from the Religious Orders Study and the Rush Memory and Aging Project, we undertook a Mendelian randomization approach integrating...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CpG Islands

Share to DNA Methylation

Share to Genetic Pleiotropy

Share to Neurofibrillary Tangles

Share to Quantitative Trait Loci

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 33120085
DOI: 10.1016/j.neurobiolaging.2020.09.019
PMCID: PMC7736197

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mendelian randomization integrating GWAS and mQTL data identified novel pleiotropic DNA methylation loci for neuropathology of Alzheimer's disease.PMID 33120085Read ↗

Novel DNA methylation loci and genes showing pleiotropic association with Alzheimer's dementia: a network Mendelian randomization analysis.Semantic proximity Read ↗

Linking DNA methylation in brain regions to Alzheimer's disease risk: a Mendelian randomization study.Semantic proximity Read ↗

Genome-wide QTL mapping across three tissues highlights several Alzheimer’s and Parkinson’s disease loci potentially acting via DNA methylationSemantic proximity Read ↗

GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia.Semantic proximity Read ↗

Integrative analysis of summary data from GWAS and eQTL studies implicates genes differentially expressed in Alzheimer's disease.Semantic proximity Read ↗

A gene-level methylome-wide association analysis identifies novel Alzheimer’s disease genesSemantic proximity Read ↗

Summary-data-based Mendelian Randomization Analysis Identifies Nominal Evidence for Association of N6-Methyladenosine Genetic Variation with Alzheimer's Disease.Semantic proximity Read ↗

Epigenome-wide analyses identify DNA methylation signatures of dementia riskSemantic proximity Read ↗

PRISM-xQTL: Pleiotropic Relationships Integrated with System-level Multiomic QTL analysis for causal genes and molecular mediators in Alzheimer's disease.Semantic proximity Read ↗

Methylation-wide association analysis reveals AIM2, DGUOK, GNAI3, and ST14 genes as potential contributors to the Alzheimer’s disease pathogenesisSemantic proximity Read ↗

Integrative multi‐omics analysis reveals the critical role of the PBXIP1 gene in Alzheimer's diseaseSemantic proximity Read ↗

Integrative Epigenomic Landscape of Alzheimer’s Disease Brains Reveals Oligodendrocyte Molecular Perturbations Associated with TauSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.