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Methylation differences in Alzheimer’s disease neuropathologic change in the aged human brain

29 Nov 2022

Abstract excerpt

Alzheimer's disease (AD) is the most common cause of dementia with advancing age as its strongest risk factor. AD neuropathologic change (ADNC) is known to be associated with numerous DNA methylation changes in the human brain, but the oldest old (> 90 years) have so far been underrepresented in epigenetic studies of ADNC. Our study participants were individuals aged over 90 years (n = 47) from The 90+ Study. We...

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PMID: 36447297
DOI: 10.1186/s40478-022-01470-0

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