Article

Local SNP-explained methylation variation reveals genetically anchored and exposure-associated methylation architecture in the human brain

2026-06-09

Abstract excerpt

Human brain DNA methylation is shaped by inherited genetic variation and cumulative environmental experience, yet how these influences partition the methylome remains poorly resolved in postmortem cohorts with modest sample sizes and limited ancestral diversity. To map this architecture in an underrepresented population, we analyzed whole-genome bisulfite sequencing and genotype array data from 168 admixed Black A...

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Literature Corpus work: e8819662-71cf-524c-8574-20c08045d4c2
DOI: 10.64898/2026.06.05.730443

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